For research use only. Not for therapeutic Use.
PD-089828（Cat No.:R027607）is a synthetic small-molecule compound recognized as a selective endothelin receptor antagonist. It has been investigated for its ability to modulate the endothelin signaling pathway, which plays a key role in vascular tone regulation, inflammation, and cardiovascular function. By inhibiting endothelin activity, PD-089828 provides a useful tool for studying mechanisms underlying hypertension, pulmonary arterial hypertension, and other cardiovascular or renal disorders. Researchers also employ it in exploring endothelin-related signaling in inflammation and fibrosis, making it valuable in pharmacological and biomedical research applications.
| CAS Number | 179343-17-0 |
| Synonyms | 1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea |
| Molecular Formula | C18H18Cl2N6O |
| Purity | ≥95% |
| IUPAC Name | 1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea |
| InChI | InChI=1S/C18H18Cl2N6O/c1-18(2,3)26-17(27)25-15-10(13-11(19)5-4-6-12(13)20)7-9-8-22-16(21)24-14(9)23-15/h4-8H,1-3H3,(H4,21,22,23,24,25,26,27) |
| InChIKey | RRWSNCZYJCOEFX-UHFFFAOYSA-N |
| SMILES | CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=C(C=CC=C3Cl)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
