PCS1055 dihydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: I011979
  • CAS Number: 361979-40-0
  • Molecular Formula: C27H34Cl2N4
  • Molecular Weight: 485.49
  • Purity: ≥95%
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PCS1055 dihydrochloride(CAT: I011979) is a potent, selective, and competitive muscarinic M4 receptor antagonist with an IC50 of 18.1 nM and a Kd of 5.72 nM. It inhibits [³H]-NMS binding with a Ki of 6.5 nM and demonstrates exceptional selectivity (>100-fold over M1, M3, M5; 30-fold over M2). PCS1055 also acts as a dual acetylcholinesterase (AChE) inhibitor, with IC50 values of 22 nM (eel AChE) and 120 nM (human AChE). Functionally, it antagonizes agonist-stimulated GTP-γ-[³⁵S] binding, showing the highest potency at M4. In vivo, intraperitoneal dosing (30 mg/kg) yields significant plasma and brain exposure, supporting its use in neurological disease research.


CAS Number 361979-40-0
Synonyms

N-[2-(1-benzylpiperidin-4-yl)ethyl]-3,4-diazatricyclo[9.4.0.02,7]pentadeca-1(15),2,4,6,11,13-hexaen-5-amine;dihydrochloride

Molecular Formula C27H34Cl2N4
Purity ≥95%
IUPAC Name N-[2-(1-benzylpiperidin-4-yl)ethyl]-3,4-diazatricyclo[9.4.0.02,7]pentadeca-1(15),2,4,6,11,13-hexaen-5-amine;dihydrochloride
InChI InChI=1S/C27H32N4.2ClH/c1-2-7-22(8-3-1)20-31-17-14-21(15-18-31)13-16-28-26-19-24-11-6-10-23-9-4-5-12-25(23)27(24)30-29-26;;/h1-5,7-9,12,19,21H,6,10-11,13-18,20H2,(H,28,29);2*1H
InChIKey VSCSFYDNGYAWKG-UHFFFAOYSA-N
SMILES C1CC2=CC=CC=C2C3=NN=C(C=C3C1)NCCC4CCN(CC4)CC5=CC=CC=C5.Cl.Cl
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