PBD-150

• CAT Number: I017183
• CAS Number: 790663-33-1
• Molecular Formula: C15H20N4O2S
• Molecular Weight: 320.41
• Purity: ≥95%
• Synonyms: 1-(3,4-dimethoxyphenyl)-3-(3-imidazol-1-ylpropyl)thiourea
• InChI: InChI=1S/C15H20N4O2S/c1-20-13-5-4-12(10-14(13)21-2)18-15(22)17-6-3-8-19-9-7-16-11-19/h4-5,7,9-11H,3,6,8H2,1-2H3,(H2,17,18,22)
• InChIKey: FZQXMGLQANXZRP-UHFFFAOYSA-N
• SMILES: COC1=C(C=C(C=C1)NC(=S)NCCCN2C=CN=C2)OC

PBD-150(CAT: I017183) is a potent inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant, with a Kᵢ of 490 nM. By targeting hQC, PBD-150 prevents the formation of pyroglutamate-modified amyloid-β (pE-Aβ) peptides, a particularly neurotoxic form implicated in Alzheimer’s disease pathology. In transgenic mouse models, PBD-150 significantly reduced brain deposition of pE-Aβ, resulting in marked improvements in learning and memory performance. Its mechanism highlights the therapeutic potential of QC inhibition in mitigating amyloid-driven neurodegeneration. PBD-150 serves as a valuable pharmacological tool for studying Alzheimer’s disease, amyloid aggregation, and neuroprotective therapeutic development.