PB131

• CAT Number: I041002
• CAS Number: 2924425-63-6
• Molecular Formula: C16H16FN3O2
• Molecular Weight: 301.32
• Purity: ≥95%
• Synonyms: 4-(3,4-dihydro-2H-1,8-naphthyridin-1-ylmethyl)-3-fluoro-N-hydroxybenzamide
• InChI: InChI=1S/C16H16FN3O2/c17-14-9-12(16(21)19-22)5-6-13(14)10-20-8-2-4-11-3-1-7-18-15(11)20/h1,3,5-7,9,22H,2,4,8,10H2,(H,19,21)
• InChIKey: IRALAZOBAVZSHO-UHFFFAOYSA-N
• SMILES: C1CC2=C(N=CC=C2)N(C1)CC3=C(C=C(C=C3)C(=O)NO)F

PB131 (Cat No.: I041002) is a potent and selective activator of Nrf2 (nuclear factor erythroid 2–related factor 2), a key transcription factor involved in cellular defense against oxidative stress. By inhibiting Keap1-mediated degradation of Nrf2, PB131 enhances the expression of antioxidant and cytoprotective genes. It is widely used in research on neurodegenerative diseases, inflammation, and cancer chemoprevention. PB131 supports studies investigating redox homeostasis, cellular resilience, and stress response pathways. For research use only in laboratory and preclinical applications.

Reference

[1]. Liu G, et al. Design, synthesis, and anti-inflammatory activity characterization of novel brain-permeable HDAC6 inhibitors. Eur J Med Chem. 2023 Jun 5;254:115327.
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