Paxilline

• CAT Number: R036312
• CAS Number: 57186-25-1
• Molecular Formula: C27H33NO4
• Molecular Weight: 435.56
• Purity: ≥95%
• Synonyms: [2R-(2α,4bβ,6aα,12bβ,12cα,14aβ)]-5,6,6a,7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-1-benzopyrano[5’,6’:6,7]indeno[1,2-b]indol-3(4bH)-one; (2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a,7,12,12b,12c,13,14,14a-Decah
• Target: Neuronal Signaling
• Storage: Store at +4C
• IUPAC Name: (1S,2R,5S,7R,11S,14S)-11-hydroxy-7-(2-hydroxypropan-2-yl)-1,2-dimethyl-6-oxa-23-azahexacyclo[12.10.0.02,11.05,10.016,24.017,22]tetracosa-9,16(24),17,19,21-pentaen-8-one
• InChI: InChI=1S/C27H33NO4/c1-24(2,30)23-20(29)14-18-21(32-23)10-11-25(3)26(4)15(9-12-27(18,25)31)13-17-16-7-5-6-8-19(16)28-22(17)26/h5-8,14-15,21,23,28,30-31H,9-13H2,1-4H3/t15-,21-,23-,25+,26+,27+/m0/s1
• InChIKey: ACNHBCIZLNNLRS-UBGQALKQSA-N
• SMILES: CC12CCC3C(=CC(=O)C(O3)C(C)(C)O)C1(CCC4C2(C5=C(C4)C6=CC=CC=C6N5)C)O

Paxilline(CAT: R036312) is a naturally occurring indole-diterpenoid alkaloid with the molecular formula C₂₇H₃₃NO₄. Isolated from Penicillium paxilli and related fungal species, it is best known as a potent and selective blocker of large-conductance calcium-activated potassium (BK) channels. Paxilline plays a key role in neurophysiological and pharmacological research, particularly in studies involving ion channel regulation, neuronal excitability, and smooth muscle function. It is typically supplied as a white to off-white crystalline powder and is soluble in DMSO, methanol, and ethanol. Paxilline’s unique structure and bioactivity make it a valuable tool in both basic neuroscience and therapeutic target validation.