PARP10/15-IN-3

• CAT Number: I043614
• CAS Number: 2892064-88-7
• Molecular Formula: C15H18N2O3
• Molecular Weight: 274.32
• Purity: ≥95%
• Synonyms: 6-(cyclopropylmethoxy)-2,3-dihydrophthalazine-1,4-dione
• IUPAC Name: 6-(cyclohexylmethoxy)-2,3-dihydrophthalazine-1,4-dione
• InChI: InChI=1S/C15H18N2O3/c18-14-12-7-6-11(8-13(12)15(19)17-16-14)20-9-10-4-2-1-3-5-10/h6-8,10H,1-5,9H2,(H,16,18)(H,17,19)
• InChIKey: PCAWJIMDNGAMRA-UHFFFAOYSA-N
• SMILES: C1CCC(CC1)COC2=CC3=C(C=C2)C(=O)NNC3=O

PARP10/15-IN-3（Cat No.:I043614）is a selective small-molecule inhibitor targeting the poly(ADP-ribose) polymerase 10 (PARP10) and PARP15 enzymes, which are involved in the regulation of DNA damage repair, cellular stress responses, and post-translational modifications of proteins. By inhibiting these enzymes, PARP10/15-IN-3 can disrupt the DNA repair mechanisms in cancer cells, making them more susceptible to DNA-damaging agents like chemotherapy and radiation. This compound holds promise as a potential therapeutic strategy in oncology, particularly in cancers with defective DNA repair mechanisms, enhancing the efficacy of conventional treatments.