For research use only. Not for therapeutic Use.
PARP1-IN-7（Cat No.:I045206）is a potent, selective inhibitor of poly(ADP-ribose) polymerase 1 (PARP1), an enzyme essential for DNA single-strand break repair via the base excision repair pathway. By blocking PARP1 activity, PARP1-IN-7 prevents DNA repair in cancer cells, leading to synthetic lethality, especially in tumors with BRCA1/2 or other homologous recombination deficiencies. It enhances the efficacy of DNA-damaging agents and radiotherapy. PARP1-IN-7 is a valuable research tool for studying DNA damage response mechanisms and holds therapeutic potential in oncology for targeted treatment of PARP1-dependent and repair-deficient cancers.
| CAS Number | 2084112-75-2 |
| Synonyms | 4-[4-[(1R)-3-(5-oxo-6H-1,6-naphthyridin-7-yl)cyclopent-2-en-1-yl]piperazin-1-yl]benzonitrile |
| Molecular Formula | C24H23N5O |
| Purity | ≥95% |
| IUPAC Name | 4-[4-[(1R)-3-(5-oxo-6H-1,6-naphthyridin-7-yl)cyclopent-2-en-1-yl]piperazin-1-yl]benzonitrile |
| InChI | InChI=1S/C24H23N5O/c25-16-17-3-6-19(7-4-17)28-10-12-29(13-11-28)20-8-5-18(14-20)22-15-23-21(24(30)27-22)2-1-9-26-23/h1-4,6-7,9,14-15,20H,5,8,10-13H2,(H,27,30)/t20-/m1/s1 |
| InChIKey | IBBZXRLLZKUNIM-HXUWFJFHSA-N |
| SMILES | C1CC(=C[C@@H]1N2CCN(CC2)C3=CC=C(C=C3)C#N)C4=CC5=C(C=CC=N5)C(=O)N4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
