Paroxetine hydrochloride

• CAT Number: I000429
• CAS Number: 110429-35-1
• Molecular Formula: C19H20FNO3.HCl
• Molecular Weight: 365.83
• Purity: ≥95%
• IUPAC Name: (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine;hydrate;dihydrochloride
• InChI: InChI=1S/2C19H20FNO3.2ClH.H2O/c2*20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;;;/h2*1-6,9,14,17,21H,7-8,10-12H2;2*1H;1H2/t2*14-,17-;;;/m00.../s1
• SMILES: C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.O.Cl.Cl

Paroxetine Hydrochloride (Cat No.: I000429) is a selective serotonin reuptake inhibitor (SSRI) commonly prescribed to treat depression, anxiety disorders, obsessive-compulsive disorder (OCD), and post-traumatic stress disorder (PTSD). It works by increasing serotonin levels in the brain, helping regulate mood and emotional balance. Paroxetine is known for its strong affinity for the serotonin transporter and relatively short half-life. Available in tablet and oral suspension forms, it is effective but may cause side effects such as drowsiness, nausea, or withdrawal symptoms upon discontinuation.

Reference

S.R. Grimsley et al. Paroxetine, sertraline, and fluvoxamine: new selective serotonin reuptake inhibitors. Clin Pharm. 1992 Nov;11(11):930-57.

D.M. Thal et al. Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility. ACS Chem Biol. 2012 Nov 16;7(11):1830-9.

L. Weber et al. Paroxetine: a first for selective serotonin reuptake inhibitors – a new use: approved for vasomotor symptoms in postmenopausal women. Womens Health (Lond Engl). 2014 Mar;10(2):147-54.