<p style=/line-height:25px/>Papaverine hydrochloride is a selective phosphodiesterase inhibitor for the PDE10A subtype found mainly in the striatum of the brain.<br>Target: PDE<br>in vitro: Papaverine is an opium alkaloid antispasmodic drug, used primarily in the treatment of visceral spasm, vasospasm (especially those involving the heart and the brain).<br>in vivo: When administered chronically to mice, Papaverine produces motor and cognitive deficits and increased anxiety, but conversely may produce an antipsychotic effect.</p>
| Catalog Number | I004309 |
| CAS Number | 61-25-6 |
| Molecular Formula | C20H22ClNO4 |
| Purity | 95% |
| Target | PDE |
| Solubility | DMSO: ≤ 6.4 mg/mL (Need ultrasonic and warming) |
| Storage | Store at -20°C |
| Reference | </br>1:Prediction of the hydroxypropyl cellulose-poly(vinyl alcohol) ratio in aqueous solution containing papaverine hydrochloride in terms of drug loaded electrospun fiber formation. Kazsoki A, Szabó P, Zelkó R.J Pharm Biomed Anal. 2017 May 10;138:357-362. doi: 10.1016/j.jpba.2017.02.030. Epub 2017 Feb 22. PMID: 28259094 </br>2:THE PROCESS OF MASS TRANSFER ON THE SOLID-LIQUID BOUNDARY LAYER DURING THE RELEASE OF DICLOFENAC SODIUM AND PAPAVERINE HYDROCHLORIDE FROM TABLETS IN A PADDLE APPARATUS. Kasperek R, Zimmer L, Poleszak E.Acta Pol Pharm. 2016 Jan-Feb;73(1):163-73. PMID: 27008811 </br>3:Influence of Polymer Type on the Physical Properties and Release Profile of Papaverine Hydrochloride From Hard Gelatin Capsules. Polski A, Iwaniak K, Kasperek R, Modrzewska J, Sobótka-Polska K, Sławińska K, Poleszak E.Polim Med. 2015 Jul-Dec;45(2):51-5. PMID: 26994886 Free Article</br>4:PHARMACOKINETICS OF DICLOFENAC SODIUM AND PAPAVERINE HYDROCHLORIDE AFTER ORAL ADMINISTRATION OF TABLETS TO RABBITS. Kasperek R, Zimmer Ł, Jawień W, Poleszak E.Acta Pol Pharm. 2015 May-Jun;72(3):527-38. PMID: 26642661 Free Article</br>5:Dissolution Studies of Papaverine Hydrochloride from Tablets in Three Pharmacopoeia Apparatuses. Polski A, Kasperek R, Rogowska M, Iwaniak K, Sobòtka-Polska K, Poleszak E.Polim Med. 2015 Jan-Jun;45(1):21-4. PMID: 26630725 Free Article</br>6:Release kinetics of papaverine hydrochloride from tablets with different excipients. Kasperek R, Polski A, Zimmer Ł, Poleszak E.Sci Pharm. 2014 May 16;82(3):684-96. doi: 10.3797/scipharm.1310-19. Print 2014 Jul-Sep. PMID: 25853076 Free PMC Article</br>7:The effect of excipients on the release kinetics of diclofenac sodium and papaverine hydrochloride from composed tablets. Kasperek R, Trebacz H, Zimmer Ł, Poleszak E.Acta Pol Pharm. 2014 May-Jun;71(3):439-49. PMID: 25265824 Free Article</br>8:[Influence of polymer type on the physical properties and the release study of papaverine hydrochloride from tablets]. Kasperek R, Polski A, Sobótka-Polska K, Poleszak E.Polim Med. 2014 Jan-Mar;44(1):5-12. Polish. PMID: 24918651 Free Article</br>9:Treatment of loin pain suspected to be renal colic with papaverine hydrochloride: a prospective double-blind randomised study. Asgari SA, Asli MM, Madani AH, Maghsoudi PA, Ghanaei MM, Shakiba M, Aval HB, Enshaei A, Farzan A, Esmaeili S.BJU Int. 2012 Aug;110(3):449-52. doi: 10.1111/j.1464-410X.2011.10793.x. Epub 2012 Feb 20. PMID: 22348304 Free Article</br>10:Simultaneous release of diclofenac sodium and papaverine hydrochloride from tablets and pellets using the flow-through cell apparatus described by dimensionless equations. Kasperek R.Acta Pol Pharm. 2011 Mar-Apr;68(2):261-72. PMID: 21485300 Free Article |
