Pam3CSK4 TFA

• CAT Number: I017278
• CAS Number: 112208-01-2
• Molecular Formula: C81H156N10O13S.3C2HF3O2
• Molecular Weight: 1852.30
• Purity: ≥95%
• IUPAC Name: (2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2R)-3-[2,3-di(hexadecanoyloxy)propylsulfanyl]-2-(hexadecanoylamino)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoic acid;tris(2,2,2-trifluoroacetic acid)
• InChI: InChI=1S/C81H156N10O13S.3C2HF3O2/c1-4-7-10-13-16-19-22-25-28-31-34-37-40-55-73(93)86-72(65-105-64-66(104-75(95)57-42-39-36-33-30-27-24-21-18-15-12-9-6-3)63-103-74(94)56-41-38-35-32-29-26-23-20-17-14-11-8-5-2)80(100)91-71(62-92)79(99)89-68(52-44-48-59-83)77(97)87-67(51-43-47-58-82)76(96)88-69(53-45-49-60-84)78(98)90-70(81(101)102)54-46-50-61-85;3*3-2(4,5)1(6)7/h66-72,92H,4-65,82-85H2,1-3H3,(H,86,93)(H,87,97)(H,88,96)(H,89,99)(H,90,98)(H,91,100)(H,101,102);3*(H,6,7)/t66?,67-,68-,69-,70-,71-,72-;;;/m0.../s1
• InChIKey: OMHVRUPOLLHATE-PXSLIBMESA-N
• SMILES: CCCCCCCCCCCCCCCC(=O)N[C@@H](CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O

Pam3CSK4 TFA(CAT: I017278) is a synthetic triacylated lipopeptide that functions as a potent Toll-like receptor 1/2 (TLR1/2) agonist. It mimics the acylated amino terminus of bacterial lipoproteins, activating innate immune pathways through NF-κB and MAPK signaling. Pam3CSK4 induces cytokine and chemokine production, making it a widely used tool for studying immune cell activation, inflammation, and host–pathogen interactions. In vitro, it stimulates dendritic cells, macrophages, and monocytes, while in vivo it enhances Th1/Th2 responses. With its defined structure and strong immunostimulatory activity, Pam3CSK4 TFA is valuable for research in immunology, vaccine adjuvant development, and infection disease modeling.