For research use only. Not for therapeutic Use.
Paltimatrectinib（Cat No.:I045097）is a selective tropomyosin receptor kinase (TRK) inhibitor designed to target TRKA, TRKB, and TRKC fusion proteins that drive tumor growth in various cancers. By blocking TRK signaling, Paltimatrectinib disrupts oncogenic pathways involved in cell proliferation and survival. It is being developed for the treatment of NTRK fusion-positive solid tumors, including those resistant to first-generation TRK inhibitors. With improved central nervous system penetration and potency, Paltimatrectinib offers promise for durable responses. Supplied for research on targeted cancer therapy, TRK fusion biology, and resistance mechanisms in oncology.
| CAS Number | 2353522-15-1 |
| Synonyms | 5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]-3-[4-(trifluoromethyl)pyrazol-1-yl]pyrazolo[1,5-a]pyrimidine |
| Molecular Formula | C20H15F5N6 |
| Purity | ≥95% |
| IUPAC Name | 5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]-3-[4-(trifluoromethyl)pyrazol-1-yl]pyrazolo[1,5-a]pyrimidine |
| InChI | InChI=1S/C20H15F5N6/c21-13-3-4-15(22)14(8-13)16-2-1-6-29(16)18-5-7-30-19(28-18)17(10-27-30)31-11-12(9-26-31)20(23,24)25/h3-5,7-11,16H,1-2,6H2/t16-/m1/s1 |
| InChIKey | FYPXPQSPRRZJCK-MRXNPFEDSA-N |
| SMILES | C1C[C@@H](N(C1)C2=NC3=C(C=NN3C=C2)N4C=C(C=N4)C(F)(F)F)C5=C(C=CC(=C5)F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
