PA-8

• CAT Number: I034142
• CAS Number: 878437-15-1
• Molecular Formula: C17H18N4O4
• Molecular Weight: 342.35
• Purity: ≥95%
• Synonyms: 2-amino-5-(3-methoxy-4-prop-2-enoxyphenyl)-3,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-4,7-dione
• InChI: InChI=1S/C17H18N4O4/c1-3-6-25-11-5-4-9(7-12(11)24-2)10-8-13(22)19-15-14(10)16(23)21-17(18)20-15/h3-5,7,10H,1,6,8H2,2H3,(H4,18,19,20,21,22,23)
• InChIKey: DCSWTWUTSKSXOV-UHFFFAOYSA-N
• SMILES: COC1=C(C=CC(=C1)C2CC(=O)NC3=C2C(=O)NC(=N3)N)OCC=C

PA-8 (Cat No.: I034142) is a synthetic compound known for its potent anti-inflammatory and neuroprotective properties. It functions primarily as a selective inhibitor of histone deacetylase 6 (HDAC6), an enzyme involved in protein degradation, cell motility, and stress response pathways. By inhibiting HDAC6, PA-8 modulates acetylation of tubulin and other cytoplasmic substrates, showing promise in treating neurodegenerative diseases and certain cancers. Its selectivity minimizes off-target effects commonly seen with broad-spectrum HDAC inhibitors, making PA-8 a valuable candidate for therapeutic research and drug development.

Reference

[1]. Ichiro Takasaki, et al. In Silico Screening Identified Novel Small-molecule Antagonists of PAC1 Receptor. J Pharmacol Exp Ther. 2018 Apr;365(1):1-8.
[Content Brief]

[2]. Ichiro Takasaki, et al. The novel small-molecule antagonist of PAC1 receptor attenuates formalin-induced inflammatory pain behaviors in mice. J Pharmacol Sci. 2019 Feb;139(2):129-132.
[Content Brief]