P8RI

• CAT Number: I044187
• CAS Number: 2147724-76-1
• Molecular Formula: C51H77N13O9
• Molecular Weight: 1016.24
• Purity: ≥95%
• Synonyms: (2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-1-[(2R)-2-[[(2R)-2,6-diaminohexanoyl]amino]-3-(1H-indol-3-yl)propanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
• InChI: InChI=1S/C51H77N13O9/c1-29(2)25-38(45(67)61-39(26-32-15-7-6-8-16-32)46(68)63-42(30(3)4)48(70)59-37(50(72)73)20-13-23-56-51(54)55)60-43(65)31(5)58-47(69)41-21-14-24-64(41)49(71)40(62-44(66)35(53)18-11-12-22-52)27-33-28-57-36-19-10-9-17-34(33)36/h6-10,15-17,19,28-31,35,37-42,57H,11-14,18,20-27,52-53H2,1-5H3,(H,58,69)(H,59,70)(H,60,65)(H,61,67)(H,62,66)(H,63,68)(H,72,73)(H4,54,55,56)/t31-,35-,37-,38-,39-,40-,41-,42-/m1/s1
• InChIKey: LXYOOXZYRDPHLW-PJJIIYKISA-N
• SMILES: C[C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H]2CCCN2C(=O)[C@@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@@H](CCCCN)N

P8RI（Cat No.:I044187）is a synthetic peptide known for its ability to inhibit the interaction between CD31 (PECAM-1) and SHP-2, a phosphatase involved in inflammatory signaling. By blocking this pathway, P8RI restores CD31’s anti-inflammatory function, helping to reduce excessive neutrophil activation and tissue damage. It has shown promise in preclinical models of inflammatory diseases, including sepsis and ischemia-reperfusion injury. P8RI’s targeted mechanism makes it a valuable tool for studying vascular inflammation and immune regulation, with potential therapeutic applications in conditions involving excessive immune cell activation and endothelial dysfunction.