For research use only. Not for therapeutic Use.
P2X3 antagonist 34（Cat No.:I016167）is a selective small-molecule inhibitor of the P2X3 receptor, a ligand-gated ion channel activated by extracellular ATP. P2X3 is predominantly expressed in sensory neurons and is strongly implicated in pain transmission, neurogenic inflammation, and chronic cough reflex pathways. By blocking P2X3 activity, this antagonist reduces neuronal hyperexcitability and attenuates hypersensitivity responses. P2X3 antagonist 34 serves as a valuable pharmacological tool for investigating purinergic signaling in sensory systems and holds therapeutic potential in neuropathic pain, chronic cough, and other inflammation-associated neurological disorders.
| CAS Number | 2417288-67-4 |
| Synonyms | methyl (3S)-3-[[2-[2,6-difluoro-4-(methylcarbamoyl)phenyl]-7-methylimidazo[1,2-a]pyridin-3-yl]methyl]piperidine-1-carboxylate |
| Molecular Formula | C24H26F2N4O3 |
| Purity | ≥95% |
| IUPAC Name | methyl (3S)-3-[[2-[2,6-difluoro-4-(methylcarbamoyl)phenyl]-7-methylimidazo[1,2-a]pyridin-3-yl]methyl]piperidine-1-carboxylate |
| InChI | InChI=1S/C24H26F2N4O3/c1-14-6-8-30-19(10-15-5-4-7-29(13-15)24(32)33-3)22(28-20(30)9-14)21-17(25)11-16(12-18(21)26)23(31)27-2/h6,8-9,11-12,15H,4-5,7,10,13H2,1-3H3,(H,27,31)/t15-/m0/s1 |
| InChIKey | HHJIZLMOCIYWJF-HNNXBMFYSA-N |
| SMILES | CC1=CC2=NC(=C(N2C=C1)C[C@@H]3CCCN(C3)C(=O)OC)C4=C(C=C(C=C4F)C(=O)NC)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
