For research use only. Not for therapeutic Use.
P053(CAT:I045991) is a potent, selective, and non-competitive ceramide synthase 1 (CerS1) inhibitor, exhibiting IC₅₀ = 0.5 μM. It is the first isoform-specific CerS inhibitor, showing nanomolar potency for hCerS1 (0.54 μM) and mCerS1 (0.46 μM), while displaying much weaker inhibition against other CerS isoforms. Functionally, P053 acts as an endogenous regulator of mitochondrial fatty acid oxidation in muscle and serves as a whole-body adiposity regulator. In vivo, oral administration (5 mg/kg, 7 days) reduces C18 ceramide levels in skeletal muscle and enhances fatty acid oxidation, attenuating triglyceride accumulation and adiposity in high-fat diet mouse models.
CAS Number | 2748196-63-4 |
Synonyms | (2S)-2-amino-4-[4-[(3,4-dichlorophenyl)methoxy]phenyl]-2-methylbutan-1-ol |
Molecular Formula | C18H21Cl2NO2 |
Purity | ≥95% |
IUPAC Name | (2S)-2-amino-4-[4-[(3,4-dichlorophenyl)methoxy]phenyl]-2-methylbutan-1-ol |
InChI | InChI=1S/C18H21Cl2NO2/c1-18(21,12-22)9-8-13-2-5-15(6-3-13)23-11-14-4-7-16(19)17(20)10-14/h2-7,10,22H,8-9,11-12,21H2,1H3/t18-/m0/s1 |
InChIKey | ZQQHXJCIFGMUPY-SFHVURJKSA-N |
SMILES | CC(CCC1=CC=C(C=C1)OCC2=CC(=C(C=C2)Cl)Cl)(CO)N |
Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |