P053

For research use only. Not for therapeutic Use.

  • CAT Number: I045991
  • CAS Number: 2748196-63-4
  • Molecular Formula: C18H21Cl2NO2
  • Molecular Weight: 354.27
  • Purity: ≥95%
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P053(CAT:I045991) is a potent, selective, and non-competitive ceramide synthase 1 (CerS1) inhibitor, exhibiting IC₅₀ = 0.5 μM. It is the first isoform-specific CerS inhibitor, showing nanomolar potency for hCerS1 (0.54 μM) and mCerS1 (0.46 μM), while displaying much weaker inhibition against other CerS isoforms. Functionally, P053 acts as an endogenous regulator of mitochondrial fatty acid oxidation in muscle and serves as a whole-body adiposity regulator. In vivo, oral administration (5 mg/kg, 7 days) reduces C18 ceramide levels in skeletal muscle and enhances fatty acid oxidation, attenuating triglyceride accumulation and adiposity in high-fat diet mouse models.


CAS Number 2748196-63-4
Synonyms

(2S)-2-amino-4-[4-[(3,4-dichlorophenyl)methoxy]phenyl]-2-methylbutan-1-ol

Molecular Formula C18H21Cl2NO2
Purity ≥95%
IUPAC Name (2S)-2-amino-4-[4-[(3,4-dichlorophenyl)methoxy]phenyl]-2-methylbutan-1-ol
InChI InChI=1S/C18H21Cl2NO2/c1-18(21,12-22)9-8-13-2-5-15(6-3-13)23-11-14-4-7-16(19)17(20)10-14/h2-7,10,22H,8-9,11-12,21H2,1H3/t18-/m0/s1
InChIKey ZQQHXJCIFGMUPY-SFHVURJKSA-N
SMILES CC(CCC1=CC=C(C=C1)OCC2=CC(=C(C=C2)Cl)Cl)(CO)N
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