For research use only. Not for therapeutic Use.
OUL35 (Cat No.: I011975) is a selective small-molecule inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1), a key enzyme in the base excision repair (BER) pathway responsible for removing oxidative DNA lesions, particularly 8-oxoguanine. By blocking OGG1 activity, OUL35 modulates DNA damage repair, influencing genomic stability, transcriptional regulation, and inflammatory responses. It is used in chemical biology and pharmacology research to study the role of OGG1 in oxidative stress–related diseases, cancer, and inflammation, and to explore therapeutic strategies targeting DNA repair mechanisms in pathological conditions.
| CAS Number | 6336-34-1 |
| Synonyms | 4-(4-carbamoylphenoxy)benzamide |
| Molecular Formula | C14H12N2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H12N2O3/c15-13(17)9-1-5-11(6-2-9)19-12-7-3-10(4-8-12)14(16)18/h1-8H,(H2,15,17)(H2,16,18) |
| InChIKey | XZRCQWLPMXFGHE-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1C(=O)N)OC2=CC=C(C=C2)C(=O)N |
| Reference | [1]. Harikanth Venkannagari, et al. Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage. Cell Chem Biol. 2016 Oct 20;23(10):1251-1260. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
