For research use only. Not for therapeutic Use.
OTS447（Cat No.:I044035）is a selective and potent inhibitor of maternal embryonic leucine zipper kinase (MELK), a serine/threonine kinase implicated in cancer cell proliferation, survival, and stemness. By targeting MELK, OTS447 disrupts oncogenic signaling pathways, particularly in cancers with elevated MELK expression such as glioblastoma, breast cancer, and leukemia. It interferes with tumor growth and enhances sensitivity to DNA-damaging agents, making it a valuable tool in cancer biology research. OTS447 is especially useful for investigating MELK’s role in cancer stem cell maintenance and its potential as a therapeutic target in aggressive, treatment-resistant tumors.
| CAS Number | 1356943-67-3 |
| Synonyms | 1-[6-(3-chloro-4-hydroxyphenyl)-4-[[4-(diethylamino)cyclohexyl]amino]quinolin-3-yl]ethanone |
| Molecular Formula | C27H32ClN3O2 |
| Purity | ≥95% |
| IUPAC Name | 1-[6-(3-chloro-4-hydroxyphenyl)-4-[[4-(diethylamino)cyclohexyl]amino]quinolin-3-yl]ethanone |
| InChI | InChI=1S/C27H32ClN3O2/c1-4-31(5-2)21-10-8-20(9-11-21)30-27-22-14-18(19-7-13-26(33)24(28)15-19)6-12-25(22)29-16-23(27)17(3)32/h6-7,12-16,20-21,33H,4-5,8-11H2,1-3H3,(H,29,30) |
| InChIKey | OSRDFHWWFIEYDB-UHFFFAOYSA-N |
| SMILES | CCN(CC)C1CCC(CC1)NC2=C3C=C(C=CC3=NC=C2C(=O)C)C4=CC(=C(C=C4)O)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
