For research use only. Not for therapeutic Use.
Os30(CAT: I040289) is a potent fourth-generation EGFR tyrosine kinase inhibitor (TKI) developed to overcome resistance caused by the C797S mutation in non-small cell lung cancer (NSCLC). It targets mutant EGFR variants with high specificity, exhibiting IC₅₀ values of 18 nM for EGFRDel19/T790M/C797S and 113 nM for EGFRL858R/T790M/C797S. Os30 inhibits EGFR phosphorylation, induces G1 phase cell cycle arrest, and promotes apoptosis in KC-0116 (BaF3-EGFRDel19/T790M/C797S) cells. Demonstrating strong antitumor activity in preclinical NSCLC models, Os30 is a valuable tool for studying EGFR-driven cancer resistance mechanisms and therapeutic intervention strategies.
| CAS Number | 2998928-68-8 |
| Synonyms | N-[2-[4-(dimethylamino)piperidin-1-yl]-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]methanesulfonamide |
| Molecular Formula | C27H33N7O2S |
| Purity | ≥95% |
| IUPAC Name | N-[2-[4-(dimethylamino)piperidin-1-yl]-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]methanesulfonamide |
| InChI | InChI=1S/C27H33N7O2S/c1-32(2)20-12-15-34(16-13-20)26-10-9-19(17-24(26)31-37(4,35)36)29-27-28-14-11-23(30-27)22-18-33(3)25-8-6-5-7-21(22)25/h5-11,14,17-18,20,31H,12-13,15-16H2,1-4H3,(H,28,29,30) |
| InChIKey | QBVWTVAJGQIBKK-UHFFFAOYSA-N |
| SMILES | CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=CC(=C(C=C4)N5CCC(CC5)N(C)C)NS(=O)(=O)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
