Orotic acid

• CAT Number: I004483
• CAS Number: 65-86-1
• Molecular Formula: C5H4N2O4
• Molecular Weight: 156.1
• Purity: ≥95%
• Synonyms: 2,4-dioxo-1H-pyrimidine-6-carboxylic acid
• Target: Nucleoside Antimetabolite/Analogue
• Solubility: DMSO: 2 mg/mL, H2O: < 1 mg/mL
• Storage: Room Temperature
• InChI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)
• InChIKey: PXQPEWDEAKTCGB-UHFFFAOYSA-N
• SMILES: C1=C(NC(=O)NC1=O)C(=O)O

Orotic acid (Cat No.:I004483) is an intermediate compound in the metabolic pathway of pyrimidines, which are essential building blocks of DNA and RNA. OA plays a crucial role in the biosynthesis of pyrimidine nucleotides, such as uridine and cytidine, which are necessary for DNA replication and protein synthesis. Additionally, OA is involved in the regulation of cell growth and proliferation. Its availability and proper metabolism are important for normal cellular functions and the maintenance of nucleotide balance in the body.

Reference

[1]. Jung, E.J., K.Y. Lee, and B.H. Lee, Proliferating effect of orotic acid through mTORC1 activation mediated by negative regulation of AMPK in SK-Hep1 hepatocellular carcinoma cells. J Toxicol Sci, 2012. 37(4): p. 813-21.
[2]. Manjeshwar, S., et al., The regulation of ribonucleoside diphosphate reductase by the tumor promoter orotic acid in normal rat liver in vivo. Mol Carcinog, 1999. 24(3): p. 188-96.
[3]. Cha, J.Y., et al., Effect of betaine on the hepatic damage from orotic acid-induced fatty liver development in rats. J Enzyme Inhib Med Chem, 2011.
[4]. Jung, E.J., et al., Role of the AMPK/SREBP-1 pathway in the development of orotic acid-induced fatty liver. J Lipid Res, 2011. 52(9): p. 1617-25.