Orexin receptor antagonist 2

• CAT Number: I044691
• CAS Number: 1457940-75-8
• Molecular Formula: C25H31N5O2
• Molecular Weight: 433.55
• Purity: ≥95%
• Synonyms: 9-(4,6-dimethylpyrimidin-2-yl)-2-[(5-methoxy-1H-indol-3-yl)methyl]-2,9-diazaspiro[5.5]undecan-1-one
• InChI: InChI=1S/C25H31N5O2/c1-17-13-18(2)28-24(27-17)29-11-8-25(9-12-29)7-4-10-30(23(25)31)16-19-15-26-22-6-5-20(32-3)14-21(19)22/h5-6,13-15,26H,4,7-12,16H2,1-3H3
• InChIKey: GKTSTVGKOKZFKP-UHFFFAOYSA-N
• SMILES: CC1=CC(=NC(=N1)N2CCC3(CCCN(C3=O)CC4=CNC5=C4C=C(C=C5)OC)CC2)C

Orexin Receptor Antagonist 2（Cat No.:I044691）is a selective small-molecule inhibitor targeting the orexin receptor type 2 (OX2R), a G-protein–coupled receptor involved in regulating wakefulness, arousal, and the sleep–wake cycle. By selectively blocking OX2R, this compound promotes sleep initiation and maintenance without significantly affecting cognitive or motor function. It offers a targeted approach for treating insomnia and other sleep disorders, potentially with fewer side effects than dual orexin receptor antagonists. Orexin Receptor Antagonist 2 is primarily used in preclinical and clinical studies exploring orexin pathway modulation for therapeutic sleep enhancement.