Orellanine

• CAT Number: R015276
• CAS Number: 37338-80-0
• Molecular Formula: C10H8N2O6
• Molecular Weight: 252.18
• Purity: ≥95%
• Synonyms: 3,3’,4,4’-Tetrahydroxy-2,2’-bipyridine-1,1’-dioxide
• Target: Phosphatase
• Storage: -20°C
• IUPAC Name: 2-(1,3-dihydroxy-4-oxopyridin-2-yl)-1,3-dihydroxypyridin-4-one
• InChI: InChI=1S/C10H8N2O6/c13-5-1-3-11(17)7(9(5)15)8-10(16)6(14)2-4-12(8)18/h1-4,15-18H
• InChIKey: JGRNMEQUBVRSQR-UHFFFAOYSA-N
• SMILES: C1=CN(C(=C(C1=O)O)C2=C(C(=O)C=CN2O)O)O

Orellanine (Cat No.: R015276) is a highly toxic bipyridine-derived alkaloid found in certain mushrooms of the Cortinarius genus, such as Cortinarius orellanus. It is known for causing severe kidney damage (nephrotoxicity), often leading to acute renal failure. Orellanine exerts its toxic effects by generating reactive oxygen species and disrupting cellular metabolism, particularly in renal tubular cells. Symptoms of poisoning are delayed, often appearing days after ingestion. Due to its potency and specificity, orellanine is also studied as a potential therapeutic agent in targeted cancer treatments.