OPSS-PEG36-acid

• CAT Number: I045964
• Molecular Formula: C83H158N2O39S2
• Molecular Weight: 1872.26
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[3-(pyridin-2-yldisulfanyl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C83H158N2O39S2/c86-81(5-80-125-126-82-3-1-2-6-85-82)84-7-9-90-11-13-92-15-17-94-19-21-96-23-25-98-27-29-100-31-33-102-35-37-104-39-41-106-43-45-108-47-49-110-51-53-112-55-57-114-59-61-116-63-65-118-67-69-120-71-73-122-75-77-124-79-78-123-76-74-121-72-70-119-68-66-117-64-62-115-60-58-113-56-54-111-52-50-109-48-46-107-44-42-105-40-38-103-36-34-101-32-30-99-28-26-97-24-22-95-20-18-93-16-14-91-12-10-89-8-4-83(87)88/h1-3,6H,4-5,7-80H2,(H,84,86)(H,87,88)
• InChIKey: YETQZNCXLDFCHR-UHFFFAOYSA-N
• SMILES: C1=CC=NC(=C1)SSCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O

OPSS-PEG36-acid(CAT: I045964) is a long, heterobifunctional PEG linker featuring an ortho-pyridyl disulfide (OPSS) group and a terminal carboxylic acid. The OPSS group selectively reacts with free thiols on cysteine residues to form cleavable disulfide bonds, enabling reversible conjugation. The carboxyl group allows further functionalization through carbodiimide (EDC/NHS) chemistry with primary amines. With a 36-unit PEG spacer, this linker provides excellent water solubility, molecular flexibility, and extended spacing for reducing steric hindrance in conjugation. OPSS-PEG36-acid is widely used in bioconjugation, antibody–drug conjugate (ADC) development, drug delivery systems, and surface modification, offering a versatile platform for redox-sensitive linkage design.