OPC-14523 hydrochloride

• CAT Number: I015043
• CAS Number: 145969-31-9
• Molecular Formula: C23H29Cl2N3O2
• Molecular Weight: 450.40
• Purity: ≥95%
• Synonyms: 1-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-5-methoxy-3,4-dihydroquinolin-2-one;hydrochloride
• InChI: InChI=1S/C23H28ClN3O2.ClH/c1-29-22-8-3-7-21-20(22)9-10-23(28)27(21)12-4-11-25-13-15-26(16-14-25)19-6-2-5-18(24)17-19;/h2-3,5-8,17H,4,9-16H2,1H3;1H
• InChIKey: SFOVXVXPFWJNBL-UHFFFAOYSA-N
• SMILES: COC1=CC=CC2=C1CCC(=O)N2CCCN3CCN(CC3)C4=CC(=CC=C4)Cl.Cl

OPC-14523 hydrochloride（Cat No.:I015043）is a selective serotonin 5-HT₄ receptor agonist developed for gastrointestinal motility disorders. By stimulating 5-HT₄ receptors in the enteric nervous system, it enhances acetylcholine release, promoting gastric emptying and intestinal transit. Preclinical and clinical studies indicate its potential in treating functional dyspepsia, chronic constipation, and irritable bowel syndrome with constipation (IBS-C). Unlike older prokinetic agents, OPC-14523 hydrochloride shows improved safety and receptor selectivity, minimizing cardiac side effects. It serves as a promising research tool for gastrointestinal pharmacology and therapeutic development in motility-related conditions.