OP-5244

• CAT Number: I033905
• CAS Number: 2381268-71-7
• Molecular Formula: C19H29ClN5O9P
• Molecular Weight: 537.89
• Purity: ≥95%
• Synonyms: [(2R)-2-[[(2R,3S,4R,5R)-5-[6-chloro-4-(cyclopentylamino)pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxyoxolan-2-yl]methoxy]-1-hydroxy-3-methoxypropan-2-yl]phosphonic acid
• IUPAC Name: [(2R)-2-[[(2R,3S,4R,5R)-5-[6-chloro-4(cyclopentylamino)pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxyoxolan-2-yl]methoxy]-1-hydroxy-3-methoxypropan-2-yl]phosphonic acid
• InChI: InChI=1S/C19H29ClN5O9P/c1-32-9-19(8-26,35(29,30)31)33-7-12-13(27)14(28)17(34-12)25-16-11(6-21-25)15(23-18(20)24-16)22-10-4-2-3-5-10/h6,10,12-14,17,26-28H,2-5,7-9H2,1H3,(H,22,23,24)(H2,29,30,31)/t12-,13-,14-,17-,19-/m1/s1
• InChIKey: BQCRMLSBGAKPFW-RTPDKIPNSA-N
• SMILES: COC[C@](CO)(OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C3=NC(=NC(=C3C=N2)NC4CCCC4)Cl)O)O)P(=O)(O)O

OP-5244（Cat No.:I033905）is a selective agonist of liver X receptor beta (LXRβ), a nuclear receptor that regulates genes involved in cholesterol efflux, lipid metabolism, and inflammation. Unlike non-selective LXR agonists, OP-5244 preferentially activates LXRβ over LXRα, minimizing adverse effects such as hepatic lipogenesis and triglyceride elevation. It promotes reverse cholesterol transport and exhibits anti-inflammatory activity, making it a promising therapeutic candidate for atherosclerosis, neurodegenerative diseases, and autoimmune disorders. OP-5244 is primarily investigated in preclinical studies aiming to harness the benefits of LXR modulation while avoiding the metabolic side effects of earlier compounds.