For research use only. Not for therapeutic Use.
Onradivir（Cat No.:I045098）is an investigational antiviral agent designed to inhibit the influenza virus polymerase complex, specifically targeting the PA endonuclease domain essential for viral RNA replication. By blocking this activity, Onradivir disrupts the viral life cycle and reduces viral load, showing potential for both treatment and prophylaxis of influenza A and B infections. It demonstrates broad-spectrum efficacy, including against drug-resistant strains. With favorable oral bioavailability and pharmacokinetics, Onradivir is under clinical evaluation. Supplied for research into antiviral drug development, influenza pathogenesis, and RNA polymerase-targeted therapeutic strategies.
| CAS Number | 2200336-20-3 |
| Synonyms | (2S,3S)-3-[[6-cyclopropyl-5-fluoro-2-(5-fluoro-2H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid |
| Molecular Formula | C22H22F2N6O2 |
| Purity | ≥95% |
| IUPAC Name | (2S,3S)-3-[[6-cyclopropyl-5-fluoro-2-(5-fluoro-2H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid |
| InChI | InChI=1S/C22H22F2N6O2/c23-12-7-13-18(29-30-19(13)25-8-12)21-27-17(11-5-6-11)15(24)20(28-21)26-16-10-3-1-9(2-4-10)14(16)22(31)32/h7-11,14,16H,1-6H2,(H,31,32)(H,25,29,30)(H,26,27,28)/t9?,10?,14-,16-/m0/s1 |
| InChIKey | JCHDJLSIYWBAHI-ZWHBIUKWSA-N |
| SMILES | C1CC2CCC1[C@@H]([C@H]2NC3=NC(=NC(=C3F)C4CC4)C5=C6C=C(C=NC6=NN5)F)C(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
