ONO-RS-082

• CAT Number: I011738
• CAS Number: 99754-06-0
• Molecular Formula: C21H22ClNO3
• Molecular Weight: 371.86
• Purity: ≥95%
• Synonyms: 4-chloro-2-[[(E)-3-(4-pentylphenyl)prop-2-enoyl]amino]benzoic acid
• InChI: InChI=1S/C21H22ClNO3/c1-2-3-4-5-15-6-8-16(9-7-15)10-13-20(24)23-19-14-17(22)11-12-18(19)21(25)26/h6-14H,2-5H2,1H3,(H,23,24)(H,25,26)/b13-10+
• InChIKey: MDVFITMPFHDRBZ-JLHYYAGUSA-N
• SMILES: CCCCCC1=CC=C(C=C1)C=CC(=O)NC2=C(C=CC(=C2)Cl)C(=O)O

ONO-RS-082 (Cat No.: I011738) is a phospholipase A₂ (PLA₂) inhibitor that blocks the hydrolysis of membrane phospholipids into arachidonic acid, a precursor of pro-inflammatory eicosanoids such as prostaglandins and leukotrienes. By inhibiting PLA₂ activity, ONO-RS-082 reduces inflammatory mediator production, making it valuable in studying inflammation, signal transduction, and membrane lipid metabolism. It is used in pharmacological and biochemical research to investigate PLA₂’s role in disease processes, including neuroinflammation, cardiovascular disorders, and cancer, as well as to evaluate anti-inflammatory drug development strategies targeting lipid signaling pathways.

Reference

[1]. H S Banga,et al. Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine. Proc Natl Acad Sci U S A.1986 Dec;83(23):9197-201.
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[2]. H Ohno, et al. Effect of phospholipase A2 inhibitors on mouse T lymphocytes. I. Phospholipase A2 inhibitors exert similar immunological activities as glycosylation inhibiting factor. Int Immunol. 1989;1(4):425-33.
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[3]. Bryan P Hurley, et al. Selective eicosanoid-generating capacity of cytoplasmic phospholipase A2 in Pseudomonas aeruginosa-infected epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011 Feb;300(2):L286-94.
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[4]. Hélène Le Ribeuz, et al. Implication of Potassium Channels in the Pathophysiology of Pulmonary Arterial Hypertension. Biomolecules. 2020 Sep 1;10(9):1261.
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