For research use only. Not for therapeutic Use.
ON 108600(CAT: I040538) is a multi-targeted kinase inhibitor with potent activity against CK2 (Casein Kinase 2), TNIK, and DYRK family kinases. It exhibits strong inhibitory potency with IC₅₀ values of 0.016 μM and 0.007 μM for DYRK1A and DYRK1B, 0.028 μM for DYRK2, 0.05 μM and 0.005 μM for CK2α1 and CK2α2, and 0.005 μM for TNIK. By targeting these critical signaling kinases, ON 108600 disrupts multiple oncogenic pathways, resulting in significant antitumor effects across various cancer models. It is a valuable chemical probe for dissecting kinase-driven cellular processes and holds strong potential in the development of novel cancer therapies.
| CAS Number | 1585246-23-6 |
| Synonyms | (2Z)-6-[(2,6-dichlorophenyl)methylsulfonyl]-2-[(4-hydroxy-3-nitrophenyl)methylidene]-4H-1,4-benzothiazin-3-one |
| Molecular Formula | C22H14Cl2N2O6S2 |
| Purity | ≥95% |
| IUPAC Name | (2Z)-6-[(2,6-dichlorophenyl)methylsulfonyl]-2-[(4-hydroxy-3-nitrophenyl)methylidene]-4H-1,4-benzothiazin-3-one |
| InChI | InChI=1S/C22H14Cl2N2O6S2/c23-15-2-1-3-16(24)14(15)11-34(31,32)13-5-7-20-17(10-13)25-22(28)21(33-20)9-12-4-6-19(27)18(8-12)26(29)30/h1-10,27H,11H2,(H,25,28)/b21-9- |
| InChIKey | DOMBZVXKSRQDOJ-NKVSQWTQSA-N |
| SMILES | C1=CC(=C(C(=C1)Cl)CS(=O)(=O)C2=CC3=C(C=C2)SC(=CC4=CC(=C(C=C4)O)[N+](=O)[O-])C(=O)N3)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
