Omeprazole metabolite Omeprazole sulfone (methoxy-d3)

• CAT Number: R006240
• CAS Number: 1189891-71-1
• Molecular Formula: C17H16D3N3O4S
• Molecular Weight: 364.43
• Purity: ≥95%
• Synonyms: 2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfonyl]-6-(trideuteriomethoxy)-1H-benzimidazole
• InChI: InChI=1S/C17H19N3O4S/c1-10-8-18-15(11(2)16(10)24-4)9-25(21,22)17-19-13-6-5-12(23-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)/i3D
• InChIKey: IXEQEYRTSRFZEO-HPRDVNIFSA-N
• SMILES: [2H]C([2H])([2H])OC1=CC2=C(C=C1)N=C(N2)S(=O)(=O)CC3=NC=C(C(=C3C)OC)C

Omeprazole sulfone (methoxy-d3)（Cat No.:R006240）is a deuterium-labeled metabolite of omeprazole, featuring three deuterium atoms on the methoxy group. As a sulfone derivative, it represents a major oxidative metabolite formed via cytochrome P450-mediated biotransformation, particularly by CYP3A4. This labeled version is primarily used as an internal standard in bioanalytical studies, especially in LC-MS/MS assays for monitoring omeprazole metabolism and pharmacokinetics. The deuterium labeling improves quantitation accuracy without affecting chemical properties. It is a valuable tool in drug metabolism research and therapeutic drug monitoring for omeprazole and related proton pump inhibitors.