Oleic-DBCO

• CAT Number: I016530
• CAS Number: 2279951-78-7
• Molecular Formula: C36H48N2O2
• Molecular Weight: 540.78
• Purity: ≥95%
• Synonyms: (Z)-N-[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]octadec-9-enamide
• InChI: InChI=1S/C36H48N2O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-25-35(39)37-29-28-36(40)38-30-33-23-18-17-21-31(33)26-27-32-22-19-20-24-34(32)38/h9-10,17-24H,2-8,11-16,25,28-30H2,1H3,(H,37,39)/b10-9-
• InChIKey: XQWJKAQVIAJNTR-KTKRTIGZSA-N
• SMILES: CCCCCCCCC=CCCCCCCCC(=O)NCCC(=O)N1CC2=CC=CC=C2C#CC3=CC=CC=C31

Oleic-DBCO(CAT: I016530) is a lipid–PEG conjugate that couples oleic acid, a naturally occurring monounsaturated fatty acid, with a dibenzocyclooctyne (DBCO) moiety. The oleic acid segment provides strong hydrophobic interactions and efficient membrane anchoring, making it suitable for incorporation into liposomes, micelles, or other lipid-based nanostructures. The DBCO group enables copper-free strain-promoted azide–alkyne cycloaddition (SPAAC) “click” chemistry, allowing rapid, bioorthogonal conjugation with azide-functionalized biomolecules under mild, catalyst-free conditions. This combination makes Oleic-DBCO a powerful tool for nanoparticle functionalization, targeted drug delivery, and cell-surface engineering, enabling stable hydrophobic incorporation with highly selective, orthogonal bioconjugation capabilities.