OICR-9429 - CAS 1801787-56-3

OICR-9429 (Cat.No:I002343) is a small molecule inhibitor that targets the protein-protein interaction between the WD repeat-containing protein 5 (WDR5) and the mixed lineage leukemia (MLL) protein. By disrupting this interaction, OICR-9429 inhibits the activity of MLL fusion proteins, which are implicated in certain types of leukemia. OICR-9429 shows promise as a potential therapeutic agent for MLL-rearranged leukemias.

Catalog Number: I002343

CAS Number: 1801787-56-3

PubChem Substance ID:355048910

Molecular Formula: C₂₉H₃₂F₃N₅O₃

Molecular Weight:555.59

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

SynonymsN-(4-(4-methylpiperazin-1-yl)-3/’-(morpholinomethyl)-[1,1/’-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide

Property

Molecular Formula: C₂₉H₃₂F₃N₅O₃
Molecular Weight555.59
Target:Histone Methyltransferase
SolubilityDMSO ≥ 32 mg/mL
Purity≥95%
StorageStore at -20°C

Computed Descriptor

IUPAC NameN-[2-(4-methylpiperazin-1-yl)-5-[3-(morpholin-4-ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1H-pyridine-3-carboxamide
InChIInChI=1S/C29H32F3N5O3/c1-35-7-9-37(10-8-35)26-6-5-22(21-4-2-3-20(15-21)19-36-11-13-40-14-12-36)16-25(26)34-28(39)23-18-33-27(38)17-24(23)29(30,31)32/h2-6,15-18H,7-14,19H2,1H3,(H,33,38)(H,34,39)
InChIKeyDJOVLOYCGXNVPI-UHFFFAOYSA-N
SMILESCN1CCN(CC1)C2=C(C=C(C=C2)C3=CC(=CC=C3)CN4CCOCC4)NC(=O)C5=CNC(=O)C=C5C(F)(F)F