OICR-9429

• CAT Number: I002343
• CAS Number: 1801787-56-3
• Molecular Formula: C₂₉H₃₂F₃N₅O₃
• Molecular Weight: 555.59
• Purity: ≥95%
• Synonyms: N-(4-(4-methylpiperazin-1-yl)-3/’-(morpholinomethyl)-[1,1/’-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
• Target: Histone Methyltransferase
• Solubility: DMSO ≥ 32 mg/mL
• Storage: Store at -20°C
• IUPAC Name: N-[2-(4-methylpiperazin-1-yl)-5-[3-(morpholin-4-ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1H-pyridine-3-carboxamide
• InChI: InChI=1S/C29H32F3N5O3/c1-35-7-9-37(10-8-35)26-6-5-22(21-4-2-3-20(15-21)19-36-11-13-40-14-12-36)16-25(26)34-28(39)23-18-33-27(38)17-24(23)29(30,31)32/h2-6,15-18H,7-14,19H2,1H3,(H,33,38)(H,34,39)
• InChIKey: DJOVLOYCGXNVPI-UHFFFAOYSA-N
• SMILES: CN1CCN(CC1)C2=C(C=C(C=C2)C3=CC(=CC=C3)CN4CCOCC4)NC(=O)C5=CNC(=O)C=C5C(F)(F)F

OICR-9429 (Cat.No:I002343) is a small molecule inhibitor that targets the protein-protein interaction between the WD repeat-containing protein 5 (WDR5) and the mixed lineage leukemia (MLL) protein. By disrupting this interaction, OICR-9429 inhibits the activity of MLL fusion proteins, which are implicated in certain types of leukemia. OICR-9429 shows promise as a potential therapeutic agent for MLL-rearranged leukemias.

Reference

[1]. Grebien F et al. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
Nat Chem Biol. 2015 Aug;11(8):571-8.

[2]. Getlik M et al. Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1). J Med Chem. 2016 Mar 24;59(6):2478-96.