For research use only. Not for therapeutic Use.
OGT-IN-2（Cat No.:I015228）is a potent and selective inhibitor of O-GlcNAc transferase (OGT), the key enzyme catalyzing O-GlcNAcylation of nuclear and cytoplasmic proteins. By blocking OGT activity, OGT-IN-2 disrupts protein post-translational modification processes that regulate transcription, signaling, and stress responses. Aberrant O-GlcNAcylation is implicated in cancer, diabetes, cardiovascular, and neurodegenerative diseases, making OGT inhibition a critical area of study. OGT-IN-2 serves as a valuable chemical probe for investigating OGT biology, exploring therapeutic targets, and advancing research in epigenetics, metabolism, and disease-related glycosylation pathways.
| CAS Number | 442665-87-4 |
| Synonyms | 3-[2-(1-adamantyl)ethyl]-2-(4-chlorophenyl)imino-4-oxo-1,3-thiazinane-6-carboxylic acid |
| Molecular Formula | C23H27ClN2O3S |
| Purity | ≥95% |
| IUPAC Name | 3-[2-(1-adamantyl)ethyl]-2-(4-chlorophenyl)imino-4-oxo-1,3-thiazinane-6-carboxylic acid |
| InChI | InChI=1S/C23H27ClN2O3S/c24-17-1-3-18(4-2-17)25-22-26(20(27)10-19(30-22)21(28)29)6-5-23-11-14-7-15(12-23)9-16(8-14)13-23/h1-4,14-16,19H,5-13H2,(H,28,29) |
| InChIKey | HLPZEZRNGAXCJH-UHFFFAOYSA-N |
| SMILES | C1C2CC3CC1CC(C2)(C3)CCN4C(=O)CC(SC4=NC5=CC=C(C=C5)Cl)C(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
