For research use only. Not for therapeutic Use.
OGT 2115 (CAT: I008402) is a potent, cell-permeable, and orally active heparanase inhibitor with an IC₅₀ of 0.4 μM. It also demonstrates anti-angiogenic activity with an IC₅₀ of 1 μM by preventing heparan sulfate degradation. In breast cancer cells, OGT 2115 suppresses metastasis under endoplasmic reticulum (ER) stress and significantly reduces invasion and migration induced by tunicamycin or Adriamycin, without diminishing Adriamycin’s antiproliferative effects. In vivo, oral dosing at 20 mg/kg yields plasma levels nearly tenfold above its heparanase IC₅₀. With dual roles in angiogenesis inhibition and metastasis regulation, OGT 2115 is a valuable tool in oncology and vascular biology research.
| CAS Number | 853929-59-6 |
| Synonyms | 2-[2-[4-[[(E)-3-(4-bromophenyl)prop-2-enoyl]amino]-3-fluorophenyl]-1,3-benzoxazol-5-yl]acetic acid |
| Molecular Formula | C24H16BrFN2O4 |
| Purity | ≥95% |
| IUPAC Name | 2-[2-[4-[[(E)-3-(4-bromophenyl)prop-2-enoyl]amino]-3-fluorophenyl]-1,3-benzoxazol-5-yl]acetic acid |
| InChI | InChI=1S/C24H16BrFN2O4/c25-17-6-1-14(2-7-17)4-10-22(29)27-19-8-5-16(13-18(19)26)24-28-20-11-15(12-23(30)31)3-9-21(20)32-24/h1-11,13H,12H2,(H,27,29)(H,30,31)/b10-4+ |
| InChIKey | LKBXWNYXDMSFQU-ONNFQVAWSA-N |
| SMILES | C1=CC(=CC=C1C=CC(=O)NC2=C(C=C(C=C2)C3=NC4=C(O3)C=CC(=C4)CC(=O)O)F)Br |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
