For research use only. Not for therapeutic Use.
Odapipam (CAT: I017596) is a selective, high-affinity dopamine D1 receptor antagonist of the benzazepine class with a Kd of 0.18 nM. It has been extensively investigated as both a pharmacological probe and a superior positron emission tomography (PET) radiotracer for imaging D1 receptor distribution and function. Metabolic studies with phenobarbital-induced rat liver microsomes identified five metabolites, including N-desmethyl-Odapipam, 1-hydroxy-Odapipam, two 3′-hydroxy-Odapipam isomers, and a dehydrogenated derivative in the dihydrobenzofuran moiety. Odapipam is widely applied in neuropharmacology, receptor characterization, and PET imaging studies, offering a valuable tool for advancing research on dopaminergic signaling and neuropsychiatric disorders.
| CAS Number | 131796-63-9 |
| Synonyms | (5S)-8-chloro-5-(2,3-dihydro-1-benzofuran-7-yl)-3-methyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol |
| Molecular Formula | C19H20ClNO2 |
| Purity | ≥95% |
| IUPAC Name | (5S)-8-chloro-5-(2,3-dihydro-1-benzofuran-7-yl)-3-methyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol |
| InChI | InChI=1S/C19H20ClNO2/c1-21-7-5-13-9-17(20)18(22)10-15(13)16(11-21)14-4-2-3-12-6-8-23-19(12)14/h2-4,9-10,16,22H,5-8,11H2,1H3/t16-/m1/s1 |
| InChIKey | SKMVRXPBCSTNKE-MRXNPFEDSA-N |
| SMILES | CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC4=C3OCC4)O)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
