OARV-771

• CAT Number: I044151
• CAS Number: 2683008-37-7
• Molecular Formula: C49H59ClN8O8S2
• Molecular Weight: 987.62
• Purity: ≥95%
• Synonyms: 2-[3-[2-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-2-oxoethoxy]propoxy]ethyl 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate
• InChI: InChI=1S/C49H59ClN8O8S2/c1-27-30(4)68-48-41(27)42(33-14-16-35(50)17-15-33)53-37(45-56-55-31(5)58(45)48)23-40(61)66-21-20-64-18-9-19-65-25-39(60)54-44(49(6,7)8)47(63)57-24-36(59)22-38(57)46(62)52-28(2)32-10-12-34(13-11-32)43-29(3)51-26-67-43/h10-17,26,28,36-38,44,59H,9,18-25H2,1-8H3,(H,52,62)(H,54,60)/t28-,36+,37-,38-,44+/m0/s1
• InChIKey: CWTFXHWWWKKEQI-QQRWPDCKSA-N
• SMILES: CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)OCCOCCCOCC(=O)N[C@H](C(=O)N4C[C@@H](C[C@H]4C(=O)N[C@@H](C)C5=CC=C(C=C5)C6=C(N=CS6)C)O)C(C)(C)C)C7=CC=C(C=C7)Cl)C

OARV-771（Cat No.:I044151）is a potent androgen receptor (AR) degrader designed as a PROTAC (Proteolysis Targeting Chimera) molecule for the treatment of prostate cancer, including castration-resistant prostate cancer (CRPC). It functions by binding to the androgen receptor and recruiting an E3 ubiquitin ligase, leading to targeted degradation of AR via the proteasome. OARV-771 effectively reduces AR protein levels and inhibits AR-driven gene transcription, overcoming resistance mechanisms seen with traditional AR antagonists. It is widely used in preclinical oncology research to evaluate the therapeutic potential of AR degradation in hormone-driven malignancies.