O-(Benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium Tetrafluoroborate

• CAT Number: R016877
• CAS Number: 125700-67-6
• Molecular Formula: C11H16BF4N5O
• Molecular Weight: 321.09
• Purity: ≥95%
• Synonyms: 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium 3-Oxide Tetrafluoroborate(1-) (1:1); 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium 3-Oxide Tetrafluoroborate(1-); O-(Benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium tetrafluoroborate; O-Benzotri
• Storage: Store at RT
• IUPAC Name: [benzotriazol-1-yloxy(dimethylamino)methylidene]-dimethylazanium;tetrafluoroborate
• InChI: InChI=1S/C11H16N5O.BF4/c1-14(2)11(15(3)4)17-16-10-8-6-5-7-9(10)12-13-16;2-1(3,4)5/h5-8H,1-4H3;/q+1;-1
• InChIKey: JKEKMBGUVUKMQB-UHFFFAOYSA-N
• SMILES: [B-](F)(F)(F)F.CN(C)C(=[N+](C)C)ON1C2=CC=CC=C2N=N1

O-(Benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium tetrafluoroborate (Cat No.: R016877) is a widely used coupling reagent in peptide synthesis. It facilitates the formation of amide bonds by activating carboxylic acids for reaction with amines, producing minimal racemization. The benzotriazole moiety enhances reactivity, while the tetrafluoroborate counterion improves solubility and handling. TBTU is valued for its high efficiency, stability, and compatibility with both solution- and solid-phase synthesis techniques. It plays a crucial role in pharmaceutical and biochemical research involving peptide and protein engineering.