NVS-PI3-4

• CAT Number: I045303
• CAS Number: 941580-60-5
• Molecular Formula: C20H26N4O3S
• Molecular Weight: 402.51
• Purity: ≥95%
• IUPAC Name: 3-[[5-(4-acetylphenyl)-4-methyl-1,3-thiazol-2-yl]carbamoylamino]-N-tert-butylpropanamide
• InChI: InChI=1S/C20H26N4O3S/c1-12-17(15-8-6-14(7-9-15)13(2)25)28-19(22-12)23-18(27)21-11-10-16(26)24-20(3,4)5/h6-9H,10-11H2,1-5H3,(H,24,26)(H2,21,22,23,27)
• InChIKey: IUPXLLWDLOWEBR-UHFFFAOYSA-N
• SMILES: CC1=C(SC(=N1)NC(=O)NCCC(=O)NC(C)(C)C)C2=CC=C(C=C2)C(=O)C

NVS-PI3-4（Cat No.:I045303）is a potent, selective inhibitor of phosphoinositide 3-kinases (PI3Ks), key enzymes in the PI3K/AKT/mTOR signaling pathway that regulate cell growth, survival, and metabolism. By blocking PI3K activity, NVS-PI3-4 suppresses downstream signaling involved in tumor progression, angiogenesis, and resistance to apoptosis. It has demonstrated strong activity in preclinical cancer models, including those with PI3K pathway mutations. Its selectivity profile allows for targeted pathway modulation with reduced off-target effects, making it a valuable tool in oncology research and a promising lead for developing novel cancer therapeutics targeting aberrant PI3K signaling.