NVS-PAK1-C

• CAT Number: I014966
• CAS Number: 2250019-95-3
• Molecular Formula: C22H23ClF3N5O
• Molecular Weight: 465.90
• Purity: ≥95%
• Synonyms: (3S)-3-[[8-chloro-11-(2,2-difluoroethyl)-3-fluoro-5H-benzo[b][1,4]benzodiazepin-6-ylidene]amino]-N,N-dimethylpyrrolidine-1-carboxamide
• InChI: InChI=1S/C22H23ClF3N5O/c1-29(2)22(32)30-8-7-15(11-30)27-21-16-9-13(23)3-5-18(16)31(12-20(25)26)19-6-4-14(24)10-17(19)28-21/h3-6,9-10,15,20H,7-8,11-12H2,1-2H3,(H,27,28)/t15-/m0/s1
• InChIKey: RVHZFZVJXGIAJF-HNNXBMFYSA-N
• SMILES: CN(C)C(=O)N1CC[C@@H](C1)N=C2C3=C(C=CC(=C3)Cl)N(C4=C(N2)C=C(C=C4)F)CC(F)F

NVS-PAK1-C（Cat No.:I014966）is a selective small-molecule inhibitor targeting p21-activated kinase 1 (PAK1), a serine/threonine kinase implicated in cytoskeletal regulation, cell proliferation, and survival. By disrupting PAK1 activity, NVS-PAK1-C interferes with downstream signaling pathways such as MAPK and PI3K/AKT, which are often dysregulated in cancer and neurological disorders. This compound is widely applied in cancer research to study tumor progression, metastasis, and drug resistance, as well as in neurological studies exploring synaptic plasticity. Its selectivity makes it a valuable tool for dissecting PAK1-specific biological functions.