NVS-CECR2-1

• CAT Number: I011288
• CAS Number: 1992047-61-6
• Molecular Formula: C27H37N5O2S
• Molecular Weight: 495.68
• Purity: ≥95%
• Synonyms: N-cyclopropyl-2-propylsulfonyl-6-[1-(2,2,6,6-tetramethylpiperidin-4-yl)indol-5-yl]pyrimidin-4-amine
• InChI: InChI=1S/C27H37N5O2S/c1-6-13-35(33,34)25-29-22(15-24(30-25)28-20-8-9-20)18-7-10-23-19(14-18)11-12-32(23)21-16-26(2,3)31-27(4,5)17-21/h7,10-12,14-15,20-21,31H,6,8-9,13,16-17H2,1-5H3,(H,28,29,30)
• InChIKey: XVECNLUKQDKOST-UHFFFAOYSA-N
• SMILES: CCCS(=O)(=O)C1=NC(=CC(=N1)NC2CC2)C3=CC4=C(C=C3)N(C=C4)C5CC(NC(C5)(C)C)(C)C

NVS-CECR2-1 (Cat No.: I011288) is a potent and selective chemical probe that targets CECR2 (Cat Eye Syndrome Chromosome Region Candidate 2), a bromodomain-containing protein involved in chromatin remodeling and transcriptional regulation. By inhibiting CECR2 activity, NVS-CECR2-1 enables researchers to study epigenetic mechanisms controlling gene expression and their roles in cancer, inflammation, and developmental biology. Its selectivity makes it a valuable tool for dissecting CECR2-specific functions without off-target effects. While not for clinical application, NVS-CECR2-1 supports drug discovery and fundamental epigenetics research.

Reference

[1]. Seul Gi Park, et al. Cytotoxic activity of bromodomain inhibitor NVS-CECR2-1 on human cancer cells. Sci Rep. 2020 Oct 1;10(1):16330.
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