For research use only. Not for therapeutic Use.
NV03（Cat No.:I017959）is a small-molecule antagonist that selectively disrupts the interaction between UHRF1 (Ubiquitin-like with PHD and RING finger domains 1) and the histone modification H3K9me3. By binding to UHRF1’s tandem Tudor domain, NV03 prevents chromatin recognition processes essential for epigenetic regulation and cancer cell survival. With a dissociation constant (Kd) of about 2.4 μM, it shows moderate binding affinity. Preclinical studies highlight its potential anticancer activity, making NV03 a valuable tool compound for investigating UHRF1-mediated epigenetic mechanisms and developing novel therapeutic strategies in oncology.
| CAS Number | 2448341-58-8 |
| Synonyms | N-[3-(diethylamino)propyl]-2-(7,12-dimethyl-9-oxo-5-thia-1,10,11-triazatricyclo[6.4.0.02,6]dodeca-2(6),3,7,11-tetraen-10-yl)acetamide |
| Molecular Formula | C19H27N5O2S |
| Purity | ≥95% |
| IUPAC Name | N-[3-(diethylamino)propyl]-2-(7,12-dimethyl-9-oxo-5-thia-1,10,11-triazatricyclo[6.4.0.02,6]dodeca-2(6),3,7,11-tetraen-10-yl)acetamide |
| InChI | InChI=1S/C19H27N5O2S/c1-5-22(6-2)10-7-9-20-16(25)12-23-19(26)17-13(3)18-15(8-11-27-18)24(17)14(4)21-23/h8,11H,5-7,9-10,12H2,1-4H3,(H,20,25) |
| InChIKey | KNZQAVKYBBYDKV-UHFFFAOYSA-N |
| SMILES | CCN(CC)CCCNC(=O)CN1C(=O)C2=C(C3=C(N2C(=N1)C)C=CS3)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
