For research use only. Not for therapeutic Use.
NV-5138 hydrochloride (Cat No.: I045582) is a brain-penetrant small-molecule activator of the mechanistic target of rapamycin complex 1 (mTORC1). Unlike traditional mTOR modulators, NV-5138 directly binds and activates sestrin, a leucine-sensing protein, thereby stimulating mTORC1 signaling without requiring amino acids. It has shown rapid antidepressant-like effects in preclinical models, making it a promising candidate for mood disorder research. NV-5138 hydrochloride is widely used to study nutrient sensing, synaptic plasticity, and the role of mTORC1 activation in neuropsychiatric and metabolic disorders.
| CAS Number | 2639392-70-2 |
| Synonyms | (2S)-2-amino-5,5-difluoro-4,4-dimethylpentanoic acid;hydrochloride |
| Molecular Formula | C7H14ClF2NO2 |
| Purity | ≥95% |
| InChI | InChI=1S/C7H13F2NO2.ClH/c1-7(2,6(8)9)3-4(10)5(11)12;/h4,6H,3,10H2,1-2H3,(H,11,12);1H/t4-;/m0./s1 |
| InChIKey | SIUFCONWYBJSOP-WCCKRBBISA-N |
| SMILES | CC(C)(CC(C(=O)O)N)C(F)F.Cl |
| Reference | [1]. Sengupta S, et al. Discovery of NV-5138, the first selective Brain mTORC1 activator. Sci Rep. 2019 Mar 11;9(1):4107. [2]. Kato T, et al. Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation. J Clin Invest. 2019 Apr 16;129(6):2542-2554. |
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