Nurr1 inverse agonist-1

• CAT Number: I045333
• CAS Number: 2758673-07-1
• Molecular Formula: C16H14N2O2
• Molecular Weight: 266.29
• Purity: ≥95%
• Synonyms: methyl 1-methyl-5-pyridin-3-ylindole-3-carboxylate
• InChI: InChI=1S/C16H14N2O2/c1-18-10-14(16(19)20-2)13-8-11(5-6-15(13)18)12-4-3-7-17-9-12/h3-10H,1-2H3
• InChIKey: CPJVLZDDECEONQ-UHFFFAOYSA-N
• SMILES: CN1C=C(C2=C1C=CC(=C2)C3=CN=CC=C3)C(=O)OC

Nurr1 inverse agonist-1 (Cat No.: I045333) is a small-molecule tool compound that selectively binds and suppresses the constitutive transcriptional activity of the neuroprotective orphan nuclear receptor Nurr1. By promoting co-repressor recruitment and inhibiting co-activator binding, it enables mechanistic studies and target validation in Parkinson’s and neurodegeneration research. Typically formulated as a DMSO stock and handled under anhydrous conditions

Reference

[1]. Zaienne D, et al. Development and Profiling of Inverse Agonist Tools for the Neuroprotective Transcription Factor Nurr1. J Med Chem. 2021 Oct 28;64(20):15126-15140.
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