Nur77 modulator 1

• CAT Number: I045463
• CAS Number: 2469975-55-9
• Molecular Formula: C28H25N5O2S
• Molecular Weight: 495.60
• Purity: ≥95%
• Synonyms: 5-[(8-methoxy-2-methylquinolin-4-yl)amino]-N-[(E)-(4-methylsulfanylphenyl)methylideneamino]-1H-indole-2-carboxamide
• InChI: InChI=1S/C28H25N5O2S/c1-17-13-24(22-5-4-6-26(35-2)27(22)30-17)31-20-9-12-23-19(14-20)15-25(32-23)28(34)33-29-16-18-7-10-21(36-3)11-8-18/h4-16,32H,1-3H3,(H,30,31)(H,33,34)/b29-16+
• InChIKey: ZDSQJUKYFCIYLG-MUFRIFMGSA-N
• SMILES: CC1=CC(=C2C=CC=C(C2=N1)OC)NC3=CC4=C(C=C3)NC(=C4)C(=O)NN=CC5=CC=C(C=C5)SC

Nur77 modulator 1 (Cat No.: I045463) is a small-molecule ligand that selectively binds to and modulates the activity of Nur77 (NR4A1), an orphan nuclear receptor involved in regulating apoptosis, inflammation, metabolism, and immune responses. Depending on context, it can influence Nur77’s transcriptional activity, affecting target gene expression in cancer, cardiovascular, and metabolic disease models. This compound is used in chemical biology research to study Nur77-mediated signaling pathways and to explore therapeutic strategies aimed at modulating orphan nuclear receptor function for disease intervention.

Reference

[1]. Baicun Li, et al. Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators. Eur J Med Chem. 2020 Oct 15;204:112608.
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