NT1-O12B

• CAT Number: I044664
• CAS Number: 2739805-63-9
• Molecular Formula: C36H60N2O4S4
• Molecular Weight: 713.13
• Purity: ≥95%
• Synonyms: 2-(octyldisulfanyl)ethyl 3-[2-(1H-indol-3-yl)ethyl-[3-[2-(octyldisulfanyl)ethoxy]-3-oxopropyl]amino]propanoate
• InChI: InChI=1S/C36H60N2O4S4/c1-3-5-7-9-11-15-27-43-45-29-25-41-35(39)20-23-38(22-19-32-31-37-34-18-14-13-17-33(32)34)24-21-36(40)42-26-30-46-44-28-16-12-10-8-6-4-2/h13-14,17-18,31,37H,3-12,15-16,19-30H2,1-2H3
• InChIKey: CUQWZMJHMHGHEV-UHFFFAOYSA-N
• SMILES: CCCCCCCCSSCCOC(=O)CCN(CCC1=CNC2=CC=CC=C21)CCC(=O)OCCSSCCCCCCCC

NT1-O12B（Cat No.:I044664）is a potent, selective small-molecule antagonist targeting TLR8 (Toll-like receptor 8), a pattern recognition receptor involved in innate immune responses. By inhibiting TLR8 activation, NT1-O12B effectively reduces the production of proinflammatory cytokines and modulates immune signaling pathways. This compound is a valuable research tool for studying TLR8-mediated inflammation in autoimmune diseases, infections, and cancer. Its high specificity allows for precise dissection of TLR8’s role without affecting related receptors like TLR7 or TLR9. NT1-O12B supports therapeutic exploration of immune modulation and inflammatory disease intervention strategies.