NSI-189 - CAS 1270138-40-3

NSI-189 (CAT:I008377) is a niacinamide piperazine derivative. It can stimulate the neurogenesis of human hippocampal neural stem cells, so it is promising for major depression, Alzheimer’s disease, center and other brain diseases. This product is used for organic synthesis, drug development, and other scientific research purposes.

Catalog Number: I008377

CAS Number: 1270138-40-3

PubChem Substance ID:348355161

Molecular Formula: C₂₂H₃₀N₄O

Molecular Weight:366.4998

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

• Synonyms: (4-benzylpiperazin-1-yl)(2-(isopentylamino)pyridin-3-yl)methanone

Property

• Molecular Formula: C₂₂H₃₀N₄O
• Molecular Weight: 366.4998
• Solubility: Soluble in DMSO, not in water
• Purity: ≥95%
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• Overview of Clinical Research: Originator Neuralstem Developer Palisade Bio; University of California, San Diego Class Antidepressants; Antihyperglycaemics; Neuroprotectants; Nootropics; Piperazines; Pyridines; Small molecules; Vascular disorder therapies Mechanism of Action Neurogenesis stimulants Orphan Drug StatusYes – Angelman syndrome New Molecular Entity Yes Available For Licensing Yes

Computed Descriptor

• IUPAC Name: (4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone
• InChI: InChI=1S/C22H30N4O/c1-18(2)10-12-24-21-20(9-6-11-23-21)22(27)26-15-13-25(14-16-26)17-19-7-4-3-5-8-19/h3-9,11,18H,10,12-17H2,1-2H3,(H,23,24)
• InChIKey: DYTOQURYRYYNOR-UHFFFAOYSA-N
• SMILES: O=C(N1CCN(CC2=CC=CC=C2)CC1)C3=CC=CN=C3NCCC(C)C