For research use only. Not for therapeutic Use.
NSC668394 (Cat No.: I033645) is a selective small-molecule inhibitor of Ezrin, a member of the ERM (Ezrin–Radixin–Moesin) protein family that links the plasma membrane to the actin cytoskeleton. By binding Ezrin, NSC668394 blocks its activation through phosphorylation at threonine 567, thereby disrupting cell shape, adhesion, and motility. This compound is widely employed to study cytoskeletal organization, signal transduction, and tumor metastasis. NSC668394 serves as a valuable tool in cancer biology and metastasis research, offering insights into Ezrin-dependent cellular processes and therapeutic targeting.
| CAS Number | 382605-72-3 |
| Synonyms | 7-[2-(3,5-dibromo-4-hydroxyphenyl)ethylamino]quinoline-5,8-dione |
| Molecular Formula | C17H12Br2N2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H12Br2N2O3/c18-11-6-9(7-12(19)16(11)23)3-5-20-13-8-14(22)10-2-1-4-21-15(10)17(13)24/h1-2,4,6-8,20,23H,3,5H2 |
| InChIKey | OHPHDPYJEHZGDE-UHFFFAOYSA-N |
| SMILES | C1=CC2=C(C(=O)C(=CC2=O)NCCC3=CC(=C(C(=C3)Br)O)Br)N=C1 |
| Reference | [1]. Bulut G, et, al. Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells. Oncogene. 2012 Jan 19;31(3):269-81. [2]. Xue Y, et, al. Phosphorylated Ezrin (Thr567) Regulates Hippo Pathway and Yes-Associated Protein (Yap) in Liver. Am J Pathol. 2020 Jul;190(7):1427-1437. [3]. Çelik H, et, al. Ezrin Inhibition Up-regulates Stress Response Gene Expression. J Biol Chem. 2016 Jun 17;291(25):13257-70. |
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