For research use only. Not for therapeutic Use.
NSC636819（Cat No.:I011158）is a small-molecule inhibitor known for its ability to disrupt the interaction between the tumor suppressor protein p53 and its negative regulator MDM2. By preventing MDM2-mediated ubiquitination and degradation of p53, NSC636819 stabilizes and activates p53, leading to enhanced transcription of pro-apoptotic and cell cycle arrest genes. It is widely used in cancer research to study p53 reactivation and explore strategies for targeting tumors with wild-type p53. NSC636819 provides a valuable tool for investigating tumor suppression mechanisms and developing p53-based anticancer therapies.
| CAS Number | 1618672-71-1 |
| Synonyms | 1,5-bis[(E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitrobenzene |
| Molecular Formula | C22H12Cl4N2O4 |
| Purity | ≥95% |
| IUPAC Name | 1,5-bis[(E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitrobenzene |
| InChI | InChI=1S/C22H12Cl4N2O4/c23-17-7-3-13(9-19(17)25)1-5-15-11-16(22(28(31)32)12-21(15)27(29)30)6-2-14-4-8-18(24)20(26)10-14/h1-12H/b5-1+,6-2+ |
| InChIKey | YYZPXBXVBQSBDG-IJIVKGSJSA-N |
| SMILES | C1=CC(=C(C=C1/C=C/C2=CC(=C(C=C2[N+](=O)[O-])[N+](=O)[O-])/C=C/C3=CC(=C(C=C3)Cl)Cl)Cl)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
