For research use only. Not for therapeutic Use.
NSC12（Cat No.:I008370）is a small-molecule fibroblast growth factor (FGF) trap that selectively binds and sequesters FGFs, preventing their interaction with FGF receptors (FGFRs). By inhibiting FGF/FGFR signaling, NSC12 disrupts pathways involved in tumor growth, angiogenesis, and tissue repair. It has shown promising anti-tumor activity in preclinical models of FGF-dependent cancers. Unlike FGFR kinase inhibitors, NSC12 acts extracellularly, offering a distinct mechanism of action. It is widely used in cancer research to study FGF-driven oncogenesis and evaluate targeted therapeutic strategies. NSC12 serves as a valuable tool for modulating FGF-related biological processes.
| CAS Number | 102586-30-1 |
| Synonyms | (1S)-4,4,4-trifluoro-1-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-3-(trifluoromethyl)butane-1,3-diol |
| Molecular Formula | C24H34F6O3 |
| Purity | ≥95% |
| IUPAC Name | 4,4,4-trifluoro-1-[(8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-3-(trifluoromethyl)butane-1,3-diol |
| InChI | InChI=1S/C24H34F6O3/c1-20-9-7-14(31)11-13(20)3-4-15-16-5-6-18(21(16,2)10-8-17(15)20)19(32)12-22(33,23(25,26)27)24(28,29)30/h3,14-19,31-33H,4-12H2,1-2H3/t14?,15-,16-,17-,18+,19?,20-,21-/m0/s1 |
| InChIKey | OHKBOEWLASAFLW-DRPHTYIMSA-N |
| SMILES | C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(CC(C(F)(F)F)(C(F)(F)F)O)O)CC=C4[C@@]3(CCC(C4)O)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
