For research use only. Not for therapeutic Use.
NSC117079(CAT: I020225) is a novel and selective PHLPP (PH domain leucine-rich repeat protein phosphatase) inhibitor that effectively prevents the dephosphorylation of Akt, a critical kinase involved in cell survival and immune responses. At a concentration of 30 μM, NSC117079 significantly increases neutrophil adhesion to fibrinogen-coated surfaces from 9.0±2.4% to 27.0±8.0% and further enhances adhesion induced by 50 ng/mL GM-CSF from 22.9±6.0% to 47.6±10.9%. However, it does not affect neutrophil transendothelial migration. This suggests that PHLPP plays a key role in regulating neutrophil adhesion via Akt signaling, making NSC117079 valuable in inflammation and immune response research.
| CAS Number | 500363-63-3 |
| Molecular Formula | C₂₀H₁₅N₃O₇S₂ |
| Purity | ≥95% |
| Target | Phosphatase |
| IUPAC Name | 1-amino-9,10-dioxo-4-(3-sulfamoylanilino)anthracene-2-sulfonic acid |
| InChI | InChI=1S/C20H15N3O7S2/c21-18-15(32(28,29)30)9-14(23-10-4-3-5-11(8-10)31(22,26)27)16-17(18)20(25)13-7-2-1-6-12(13)19(16)24/h1-9,23H,21H2,(H2,22,26,27)(H,28,29,30) |
| InChIKey | LHSBZAWDPSTOEY-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C(=O)C3=C(C2=O)C(=C(C=C3NC4=CC(=CC=C4)S(=O)(=O)N)S(=O)(=O)O)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
