NSC 80467

• CAT Number: I044653
• CAS Number: 101982-51-8
• Molecular Formula: C24H22BrN3O5
• Molecular Weight: 512.35
• Purity: ≥95%
• Synonyms: 2-methyl-1-(2-methylpropyl)-3-[2-(4-nitrophenyl)-2-oxoethyl]benzo[f]benzimidazol-3-ium-4,9-dione;bromide
• InChI: InChI=1S/C24H22N3O5.BrH/c1-14(2)12-25-15(3)26(13-20(28)16-8-10-17(11-9-16)27(31)32)22-21(25)23(29)18-6-4-5-7-19(18)24(22)30;/h4-11,14H,12-13H2,1-3H3;1H/q+1;/p-1
• InChIKey: SDVDJIZVNFVMLG-UHFFFAOYSA-M
• SMILES: CC1=[N+](C2=C(N1CC(C)C)C(=O)C3=CC=CC=C3C2=O)CC(=O)C4=CC=C(C=C4)[N+](=O)[O-].[Br-]

NSC 80467（Cat No.:I044653）is a potent small-molecule compound known for its dual activity as a DNA-damaging agent and survivin (BIRC5) expression inhibitor. It induces DNA damage markers such as γH2AX and pKAP1 and inhibits DNA synthesis at submicromolar concentrations. NSC 80467 also suppresses survivin protein levels in cancer cells like PC3, contributing to apoptotic signaling. With a molecular formula of C₂₄H₂₂BrN₃O₅ and molecular weight of 512.35 g/mol, it is soluble in DMSO and widely used in cancer research to study survivin-targeted therapies and DNA-damage response pathways.