NSC 617145

• CAT Number: R028298
• CAS Number: 203115-63-3
• Molecular Formula: C13H10Cl4N2O4
• Molecular Weight: 400.04
• Purity: ≥95%
• Synonyms: 3,4-dichloro-1-[3-(3,4-dichloro-2,5-dioxopyrrol-1-yl)-2,2-dimethylpropyl]pyrrole-2,5-dione
• InChI: InChI=1S/C13H10Cl4N2O4/c1-13(2,3-18-9(20)5(14)6(15)10(18)21)4-19-11(22)7(16)8(17)12(19)23/h3-4H2,1-2H3
• InChIKey: PCOXPBOKDABARQ-UHFFFAOYSA-N
• SMILES: CC(C)(CN1C(=O)C(=C(C1=O)Cl)Cl)CN2C(=O)C(=C(C2=O)Cl)Cl

NSC 617145 (Cat No.: R028298) is a synthetic small-molecule compound identified through the National Cancer Institute’s chemical library as an experimental research agent. It has been investigated for its ability to modulate DNA damage responses and cellular signaling pathways relevant to cancer biology. Researchers use NSC 617145 in preclinical studies to explore mechanisms of apoptosis, genomic stability, and potential anticancer activity. While its precise therapeutic applications remain under investigation, NSC 617145 provides a valuable tool for probing molecular mechanisms and supporting oncology-focused drug discovery research.

Reference

[1]. Monika Aggarwal, et al. Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway. Cancer Res. 2013 Sep 1;73(17):5497-507.
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[2]. R Moles, et al. WRN-targeted therapy using inhibitors NSC 19630 and NSC 617145 induce apoptosis in HTLV-1-transformed adult T-cell leukemia cells. J Hematol Oncol. 2016 Nov 9;9(1):121.
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